Research Experience

Bioinformatics Statistical analysis of DNA microarrays as diagnostic tools for pathogens, cancer and immune system development
Biochemistry Research on the function of ion channels and naturally occurring and synthetic pore forming peptides (nanotubes).

Drug discovery

Development of drug screening assays for novel ion channel and receptor proteins including training of senior scientist in voltage-and patch-clamp techniques

Patents

US 6,365,370 DNA encoding a human subunit 5-HT3-C of the 5HT3 serotonin receptor, April 2, 2002

US 7,109,296

Human 5-HT3-C protein , September 19, 2006

Publications

Bioinformatics Bioinformatics Basics: Applications in Biological Science and Medicine Lukas K. Buehler, PhD &
Hooman H. Rashidi, MD
2nd edition, CRC Press, 2005
 
Microarray Analysis Normalizing DNA microarray data. Bilban M, Buehler LK, Head S, Desoye G, Quaranta V. Curr Issues Mol Biol. 2002, 4:57-64. Review.
  Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer. Bilban M, Buehler L, Head S, Desoye G, Quaranta V. BMC Genomics. 2002 17:19.
  Practical approaches to long oligonucleotide-based DNA microarray: lessons from herpesviruses. Wagner EK, Ramirez JJ, Stingley SW, Aguilar SA, Buehler L, Devi-Rao GB, Ghazal P. Prog Nucleic Acid Res Mol Biol. 2002;71:445-91.
  Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. Niederberger N, Buehler LK, Ampudia J, Gascoigne NR. J Leukoc Biol. 2005 May;77(5):830-41.
     
Drug Discovery Can Genetic Algorithms Solve the Problems with Predictive Biology? Buehler, LK, 2005 Pharmaceutical Discovery (December)
 

On Predicting Side Effects and the Limitations of Rational Drug Design.

Buehler, LK,2005
Pharmaceutical Discovery (September)
  Is Genomics Advancing Drug Discovery? Buehler, LK,2005, Pharmaceutical Discovery (February)26-28 (pdf)
  Advancing Drug Discovery: Beyond Design. Buehler, LK, 2004, PharmaGenomics, (July)24-26
  From Ion Channels Flow Fresh Discovery Approaches. Buehler, LK, 2004, PharmaGenomics, (February)16-19
  Beyond Recognition. Buehler, LK, 2003, PharmaGenomics, 3(8):26-30
  What's in a Structure. Buehler, LK, 2003, PharmaGenomics, 3(5):20-21.
  Bioinformatics - From tool to new scientific discipline. Buehler, LK, 2002,
New Drugs, 2:34-38
.
 


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